New, more infectious strain of Covid-19 now dominates global cases of virus?

6th July 2020

Researchers have shown that a variation in the viral genome of Covid-19 improved its ability to infect human cells and helped it become the dominant strain circulating around the world today.

  • Researchers tracking the spread of Covid-19 around the world have discovered that viruses with a new variant have now overtaken the original strain
  • Analysis of the virus’s genome sequence found a mutation called ‘D614G’ made the virus more infectious than the original strain, but did not cause more severe disease
  • The global research team, including scientists from the University of Sheffield, had previously noted the rapidly increasing prevalence of viruses with D614G throughout the world

Researchers have shown that a variation in the viral genome of Covid-19 improved its ability to infect human cells and helped it become the dominant strain circulating around the world today.

The study, published today in the journal Cell, shows the variation is more infectious in cell cultures under laboratory conditions. The variant, named ‘D614G’, makes a small but effective change in the ‘spike’ glycoprotein that protrudes from the surface of the virus, which it uses to enter and infect human cells.

The D614G variant of Covid-19 quickly took over as the dominant strain soon after it first appeared, with geographic samples showing a significant shift in viral population from the original, to the new strain of the virus.

Researchers from the Los Alamos National Laboratory in New Mexico and Duke University in North Carolina, partnered with the University of Sheffield’s Covid-19 Genomics UK research group to analyse genome samples published on GISAID, an international resource for sharing genome sequences among researchers worldwide.

Dr Thushan de Silva, Senior Clinical Lecturer in Infectious Diseases at the University of Sheffield, led analysis of data from Sheffield. He said:

“We have been sequencing SARS-CoV-2 strains in Sheffield since early in the pandemic and this allowed us to partner with our collaborators to show this mutation had become dominant in circulating strains. The full peer-reviewed study published today confirms this, and also that the new D614G genome mutation variant is also more infectious under laboratory conditions.

“Data provided by our team in Sheffield suggested that the new strain was associated with higher viral loads in the upper respiratory tract of patients with Covid-19, meaning the virus’s ability to infect people could be increased.

“Fortunately at this stage, it does not seem that viruses with D614G cause more severe disease.”

Dr Bette Korber, from the Los Alamos National Laboratory in New Mexico, was the lead author of the study. She said:

“It is possible to track SARS-CoV-2 (Covid-19) evolution globally because researchers worldwide are rapidly making their viral sequence data available through the GISAID viral sequence database. Currently tens of thousands of sequences are available through this project, and this enabled us to identify the emergence of a variant that has rapidly become the globally dominant form.”

New supporting experiments, more extensive sequencing and clinical data, and improved statistical models have been published today in full at Cell, however the researchers are keen to stress that further laboratory analysis in live cells needs to be done to determine the full implications of the mutation.

“It’s remarkable to me,” commented Dr Will Fischer, from Los Alamos National Laboratory and an author on the study. “That this increase in infectivity was detected by careful observation of sequence data alone, and that our experimental colleagues could confirm it with live virus in such a short time.”

The researchers will continue to monitor other mutations in the virus to help fight Covid-19 at a global level.

You might also be interested in

Is your Business Future Ready?

Fri 14th February 2025

The business landscape is evolving faster than ever, and staying ahead requires insight, agility, and future-ready strategies. Is your Business ready?

Progressive Safety Celebrate 65 Years in Business

Fri 14th February 2025

As Progressive Safety steps into its 65th year of operation, the company reflects on an incredible journey that has transformed it from a local supplier to a trusted name in safety equipment across the globe.

CatVideoFest Returns to Sheffield this World Cat Day

Thu 13th February 2025

Following a successful debut last year, CatVideoFest returns to Sheffield – this time at the Odeon Luxe Sheffield on World Cat Day (February 17).

Introducing OALO Security

Wed 12th February 2025

As a Sheffield-based company, we are committed to supporting the local business community by providing cyber security solutions to safeguard organisations against digital threats.