New research into stem cell mutations could improve regenerative medicine

18th May 2020

Research from the University of Sheffield has given new insight into the cause of mutations in pluripotent stem cells and potential ways of stopping these mutations from occurring.

  • New research from the University of Sheffield into stem cells could help make regenerative medicine safer
  • Regenerative medicine involves using pluripotent stem cells to repair damaged or diseased tissues in the body
  • The new research has suggested ways to reduce the likelihood of mutations occurring in these cells when cultured

Research from the University of Sheffield has given new insight into the cause of mutations in pluripotent stem cells and potential ways of stopping these mutations from occurring.

The findings, published in Stem Cell Reports, show that pluripotent stem cells are particularly susceptible to DNA damage and mutations compared to other cells, and this could cause genetic mutations.

Pluripotent stem cells are able to develop into any cell type in the body, and there is considerable interest in using them to produce cells to replace diseased or damaged tissues in applications referred to as regenerative medicine.

One concern for the safety of this is that these cells often acquire recurrent mutations which might lead to safety issues if used in patients.

The researchers have found that these mutations are more likely to occur in a certain point during their cell cycle and have suggested ways of growing the cells to dramatically reduce the susceptibility to DNA damage and potentially the mutations that arise.

Peter Andrews, Professor of Biomedical Science at the University of Sheffield, said:

“Clinical trials of regenerative medicine using cells derived from pluripotent stem cells are now beginning around the world, but there are concerns that mutations in the pluripotent stem cells may risk patient safety. Our results may allow us to significantly reduce that risk.

“Understanding the genetic stability of human pluripotent stem cells is an area developed at the University of Sheffield and one in which we are an international lead.”

The Department of Biomedical Science at the University of Sheffield carries out world-leading research to understand disease, improve treatments, and find potential cures. Researchers work in areas ranging from cell biology and developmental biology to neuroscience and regenerative medicine, with expertise in topics including stem cells and cancer.

 

You might also be interested in

Sheffield Wednesday Football Club Partner with Mini First Aid Sheffield

Tue 23rd July 2024

Mini First Aid Sheffield and Sheffield Wednesday FC Community Programme (SWFCCP) are delivering life-saving first aid sessions to mums and babies funded by Sheffield Family Hub.

Sheffield FC Partners with Quickplay Sport

Mon 22nd July 2024

Sheffield FC are thrilled to announce that The Club have partnered with Quickplay - The World's First Football Club now with The World's Best Equipment.

Rich Davies joins Jibba Jabba as Director

Mon 22nd July 2024

We’re delighted to announce the new appointment of Director, Rich Davies. Rich’s appointment comes after we have experienced a period of significant growth and new client wins.

MEPS International Renew as Stadium Sponsor at The Home of Football

Fri 19th July 2024

Sheffield FC are delighted to announce that MEPS International will remain as our stadium sponsor for the 2024/25 season.